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prf duoREGENERATIVE MEDICINE - Hard & soft tissue engineering

One of the most efficient, modern ways of promoting wound healing is the increased utilization of blood-derived growth factors. One of the first steps in this direction was the application of the so-called Platelet Rich Plasma (PRP) by Marx in 1998. Platelet Rich Fibrin (PRF) is its an advanced, second-generation solution. The difference between PRP and PRF lies in the fact that while the former has no fibrin and only few white blood cells, PRF is “rich” in fibrin and leukocytes, and it’s free of heparin and any other additives.

The PRF methodology was developed by Dr. Joseph Choukroun (surgeon, anaesthesiologist, pain specialist) in 2001, and it has become popular all over the world by now. The process requires the patient’s own venous blood, which is centrifuged without adding anti-coagulants. The natural coagulation process results in a coagulated, leukocyte and platelet rich fibrin mass. The strong fibrin net serves as an extra-cellular matrix while the growth factors of the leukocytes and platelets embedded and concentrated in the fibrin are released more slowly and therefore have an extended effect. Beside the growth factors, PRF also stores and releases pro-inflammatory cytokines which are active in the proliferative, exudative stage of the wound healing process, as well as anti-inflammatory cytokines which regulate initial tissue formation.

The further development of the PRF concept involves centrifugation at a lower speed, which increases the number of leukocytes and the quantity of growth factors as well as enhances the matrix characteristics. This upgrade allowed for the development of two new protocols: Advanced – PRF => A-PRF and Injectable PRF => i-PRF. The prepared A-PRF can be used for making membranes, it can be combined with bone substitutes and i-PRF as well.

The recommended indication areas for PRF technology application: maxillo-facial surgery (alveolus-preservation, augmentation, sinus-elevation, dental implantation), various areas of periodontology (regenerative surgery, reconstructive surgery), orthopaedics, dermatology, facial aesthetics and plastic surgery. Due to the fact that it also provides many embryonic stem cells, the use of i-PRF is highly recommended in such tissue regeneration procedures as cartilage, tendon, bone, soft tissue and, last but not least, facial aesthetic treatments.

The two existing fibrins (A-PRF and i-PRF) were complemented by four others (i-PRF+, I-PRFM, A-PRFLiquid, L-PRF) at the IDS exhibition in March 2017.

Other products offered in connection with the PRF technology: *Soft brushing kit, *Fast system, *DermoPen, *Veinlite and the *PRF Fleece HD collagen membranes as well as the refill accessories (the latest additions being the A-P and I-P tubes, BC-12 blood collectors) are available in our  webshop as well.

The manufacturer’s centrifuge catalogue is available here.

 

webSHOP PRODUCT CATALOGUE CASE STUDY VIDEOS

 

Refill kits

The Process for PRF technology requires a regular supply of certain “wear and tear” items.

 

Such items include the A-PRF tubes used for producing the advanced PRF, i.e., A-PRF membranes and sticky bone as well as the I-PRF tubes for producing the injectable PRF (I-PRF).

 

The blood collection process requires the safety B-12 blood collector devices, equipped with protection against random needle pricks. Case study video

 

All the three products are applied in closed systems with CE0123 certification.

Refill kits

Veinlite

As it is well known, many dentists have difficulties with venous blood collection. The first stage of the PRF technology is blood collection, which can be made easier and simpler by the American Veinlite vein finder instruments.

 

This is a 2nd generation device that illuminates the deep veins with a reddish light and the superficial ones with a whitish light.  Case study video

Veinlite

DermoPen

A branded product of Process for PRF, it is used in facial aesthetic treatments.

DermoPen

Fast system

Provide a tension- and pressure-free operation area with the help of screw-fixed titanium meshes for a successful and quick bone regeneration. Case study video

Fast system

Soft Brushing kit

The instruments of the Soft Brushing kit allow you to extend the flap up to 3-5 cm by disorganizing the collagen fibres of the fibrous periosteum without incision or causing any harm. Case study video

Soft Brushing kit